Vaccine Menveo Meningococcal (A C W-135 & Y) SM

MENVEO consists of one vial containing the lyophilised Meningococcal Group A (MenA) Conjugate Component plus excipients, and one syringe or vial containing the liquid Meningococcal Groups C, W-135 and Y (MenCWY) Conjugate Component plus excipients. The reconstituted sterile liquid vaccine is administered by intramuscular injection and contains meningococcal serogroup A, C, W-135 and Y oligosaccharides conjugated individually to Corynebacterium diphtheriae CRM197 protein. The polysaccharides are produced from fermentation and purification of Neisseria meningitidis (serogroups A, C, W-135 or Y). MenA, MenW-135 and MenY polysaccharides are purified by several extraction and precipitation steps. MenC polysaccharide is purified by a combination of chromatography and precipitation steps. The protein carrier (CRM197) is produced by bacterial fermentation and is purified by a series of chromatography and ultrafiltration steps. The oligosaccharides are prepared by hydrolysis, sizing, activation and conjugation. Each oligosaccharide is covalently linked to the CRM197. The resulting glycoconjugates are purified to yield the four drug substances, which compose the final vaccine. No preservative or adjuvant is added during manufacturing. The vaccine contains no thiomersal