Phenol In Almond Oil Ampoules 5 x 5ml Haemorol SM

Phenol is a colourless or faintly pink or faintly yellow deliquescent crystalline solid. It is soluble in water, and very soluble in alcohol, chloroform, ether, glycerol and fixed and volatile oils. Haemorol is a clear, yellowish, viscous solution containing 250 mg phenol in almond oil to 5 mL (phenol 5% w/v). PHARMACOLOGY Phenol is an antiseptic and disinfectant. It is also corrosive. When applied to mucous membranes, it causes the surface to become white and opaque due to precipitation of proteins, and a slough is formed. When Haemorol is injected into parahaemorrhoidal submucosa, fibrosis is produced, fixing the mucosa to the underlying muscle. Pharmacokinetics Phenol is readily absorbed through intact skin, mucous membranes and the gastrointestinal tract. It is metabolised in the liver, mainly via conjugation to phenyl glucuronide and phenyl sulfate, although small amounts are oxidised to catechol and quinol prior to further conjugation. The metabolites are excreted in the urine. Ninety-nine percent of an absorbed dose is excreted in the urine in 24 hours. The extent of systemic absorption of Haemorol following submucosal administration (when used in the treatment of haemorrhoids) is not known. Since Haemorol produces submucosal fibrosis, fixing the mucosa to the underlying muscle, the amount of phenol entering the systemic circulation would be minimal.